Therapies for complement disorders

The complement system is a vital pathway acting within the immune system. It comprises a group of proteins that recognize viral and bacterial patterns, trigger inflammation, and break up the pathogens. Excessive complement-induced inflammation, though, is associated with disease such as kidney conditions, dry AMD, and even severe cases of Covid-19. Most of these indications cannot be treated to date.

An early component in the cascade of complement action, factor H, protects the body’s own cells and regulates the inflammation process. Unrestrained inflammation due to insufficient factor H leads to fatal tissue damage. Current methods to avoid this rely on artificial antibodies that block the pathway altogether. However, this measure also stops the inactivation of pathogens and causes a significant risk of infection.

Conversely, supplemented factor H allows for regulated defense, while preserving the integrity of the host cells. Factor H is a complex protein that is difficult to produce. Only moss has been able to yield human-like, high-quality factor H, thus being a key enabler for factor H as a treatment.

Compleva FH/CPV-104: natural complement regulator

Compleva FH/CPV-104 for patients suffering from
C3 glomerulopathy (C3G)

In C3G, the complement component 3 (C3) accumulates in the filtration units of the kidney (glomeruli), leading to substantial damage and ultimately to end stage renal disease. A single administration of moss-made Compleva FH effectively reduces C3-deposition in mice kidneys.

RESEARCH
PRECLINICAL
PHASE I
PHASE II
Compleva FH is currently in the preclinical stage an is expected to enter clinical development in H1 2025.

Contact

We look forward to hearing from you!

eleva GmbH
Hans-Bunte-Str. 19
79108 Freiburg
Germany

Phone: +49 761 470 99 0
hello@elevabiologics.com

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