About the complement system and Factor H
The human immune defence is divided into two strands: the adaptive system with antibodies and the innate complement system. The complement system consists of a group of proteins that recognize viral and bacterial patterns, trigger inflammation, and break up the pathogens. Factor H ensures that the system only attacks foreign cells by binding to host cells and regulates the main inflammation component, C3a.
Genetically derived lack of factor H dials up the amount of C3a, leading to immoderate inflammation and consequently tissue damage. A surplus of factor H, on the other hand, reduces the amount of C3a. Complement-associated diseases comprise kidney diseases and dry AMD.